DIABETICS BENEFIT FROM GLUTATHIONE AND GSH-Immunity®
Vision problems Constant thirst
Atherosclerosis Muscle weakness
Cystitis Tingling & numbness in hands and feet
Fatigue Frequent urination
Candidiasis Foot infections
- Diabetes mellitus is a metabolic disease that can affect many systems in the body.
- Type 1 diabetes occurs when the pancreas does not produce insulin, which is necessary for the metabolism
of glucose (sugar) in the body.
- Type 2 diabetes (also known as adult-onset diabetes) occurs when production of insulin is inadequate or the
body is unable to properly utilize insulin.
- Long-term complications are most common in those with poorly-controlled diabetes.
- Cardiovascular Disease
Diabetes can cause cholesterol levels to increase, leading to cardiovascular (heart and vessels disease).
(atherosclerosis). According to the National Diabetes Information Clearinghouse, fatty deposits narrow
the opening in the vessels throughout the body, so the heart has to pump harder to circulate the blood,
causing the blood pressure to rise.
- The coronary arteries that feed the heart muscle may become clogged, depriving the heart muscle of
adequate oxygen and causing angina (heart pain). Clots may form in the narrow vessels, break loose and travel
to the heart (causing a heart attack), to the brain (causing a stroke) or to the lungs (causing a pulmonary
- Peripheral Vascular Disease
As the blood vessels narrow in the legs, peripheral circulation to the lower legs and feet becomes
increasingly impaired, and the blood isn't able to carry enough oxygen to nourish the tissues, so the
tissues damage easily and heal slowly. The lack of circulation may cause pain in the legs, especially when
walking. In some cases, ulcers (open wounds) develop and may become gangrenous, leading to amputation of
the toes and/or foot and sometimes part of the leg.
- Eye Disease
The National Eye Institute outlines the damage that diabetes causes in the eyes. Retinopathy, the
most common disorder, occurs when the vessels in the eye do not adequately provide nourishment to the
retina. Sometimes new vessels form on the retina to compensate, but these can interfere with vision. Diabetics
are also at increased risk for cataracts and also for glaucoma, in which eye pressure increases as the eye fails
to drain properly. The increased pressure damages the optic nerve and can cause blindness.
Additionally, nerve damage associated with diabetes may prevent the pupil from reacting properly to light,
interfering with vision, especially at night.
According to the NDIC, up to 70 percent of people with diabetes develop some degree of neuropathy
(nerve damage) because of excess glucose levels. Neuropathy may range from slight numbness or tingling in
the hands or feet to severe lack of sensation and pain and weakness. Neuropathy can affect various
systems, such as the autonomic nervous system, resulting in impaired digestion with nausea, vomiting,
constipation and/or diarrhea. It can impair urination so that the bladder fails to empty completely or the person
doesn't feel the urge to urinate.
- Erectile Dysfunction
Diabetes is one of the primary causes of erectile dysfunction. An erection occurs when nerves send
a message to the muscles of the corpus cavernosa in the penis to relax so that the spongy tissue can fill
with blood. With diabetes, the nerve impulses are impaired, so the muscles don't relax adequately, and
the circulation to the corpus cavernosa may be impaired as well so that the tissue can't fill with blood.
- Kidney Disease
High blood pressure and high glucose levels resulting from diabetes may damage the filtering parts of
the kidney, the glomeruli. As blood is filtered through the kidneys, normal kidneys retain the proteins,
returning them to the blood, and filter out waste products, sending them to the urine. According to the NDIC,
when the glomeruli are damaged so that they can't filter properly, protein begins to leak into the urine, and
waste products build up in the blood. Over time, the kidneys may fail to function completely as more
damage occurs, and the person may need dialysis to remove waste from the blood.
- Periodontal Disease
Circulatory impairment of the vessels that provide oxygen and nourishment to the gums can lead
to periodontal disease and tooth loss in those with diabetes.
GLUTATHIONE'S ROLE IN DIABETES
GSH plays an important role in the fight against diabetes.
- can prevent circulatory problems such as arteriosclerosis and stroke - the main causes of diabetic death .
- GSH also enhances the Immune system, this aids the body in fighting infections that can be serious to a
diabetic because healing is hard for a diabetic to accomplish.
- Elevated GSH levels may help by providing:
- Immune system support against infection
- Decrease of oxidative stress from hyperglycemia
- Decrease of platelet aggregation
- Prevention of vascular complications including:
- Atherosclerosis (as well as heart disease, stroke)
- Nephropathy (kidney damage)
- Retinopathy (retinal damage)
- Neuropathy (nerve damage)
- It is clear that the small blood vessels of diabetics are subject to accelerated degeneration, but the causes of
this particular illness are still being identified. Recent studies demonstrate that diabetics are more prone than
others to oxidative stress and free radical formation.
In fact, the blood and tissues of diabetics are marked by critically low GSH levels, removing free radicals and
helping oxidative stress are 2 main functions of Glutathione. SO when a diabetic is low in levels of Glutathione
then it is very hard for the body to protect from these problems.
- R.K. Sundaram's studies suggest that this antioxidant deficiency of Glutathione precedes the subsequent
complications of diabetes.
- K. Yoshida and his research group have shown that low or weak GSH synthesis leads to increased cellular
damage and other complications.
Going one step further,
- Thornalley's trials revealed a correspondence between low GSH levels and higher diabetic complications.
- S.K.Jain and R. Me Vie suggest that the low GSH levels characteristic of diabetes play a role in impaired insulin
secretion in uncontrolled diabetic patients.
- Many researchers have established a link between low GSH levels and a higher likelihood of endothelial
with increased platelet aggregation.
- Other researchers have looked more specifically at the relationship of GSH to isolated complications such
as hypertension, diabetic neuropathy and nephropathy, with favorable results. The role of GSH in
protecting red blood cells from oxidative damage in the case of renal dialysis is also very promising
- Inflammation leads to and contributes to insulin resistance. Glutathione, on top of being the most potent
antioxidant, is also a powerful ant-inflammatory.
- "Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major
role in the pathogenesis of both types of diabetes mellitus. Free radicals are formed disproportionately in
diabetes ….Abnormally high levels of free radicals and the simultaneous decline of antioxidant defense
mechanisms can lead to ….development of insulin resistance. These consequences of oxidative stress can
promote the development of complications of diabetes mellitus." © 2003 Wiley Periodicals, Inc. J Biochem Mol
Toxicol 17:24-38, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.
- "…there is evidence for increased oxidative stress in diabetes….With regard to diabetes,
antioxidants…supplementation have been shown to be beneficial…Thus, it appears that, in diabetes, antioxidant
therapy could alleviate the increased attendant oxidative stress and emerge as an additional therapeutic
modality." Vega-Lopez S, Devaraj S, Jialal I: Oxidative stress and antioxidant supplementation in the
management of diabetic cardiovascular disease. J Investig Med 2004, 52(1):24-32. PubMed
- "Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered that
inflammation…leads to insulin resistance and Type 2 diabetes." ScienceDaily (Nov. 7, 2007)
As you can see an adaquate level of Glutathione in the body aids the diabetic to
maintain health in respect to their Circulatory System, Kidneys, Cardiovascular and