Liver

GLUTATIONE IS CRUCIAL FOR OUR LIVER HEALTH

Normal GLUTATHIONE levels in LIVER cells can be up to 85% intracellular because of the jobs that the liver preforms in the body.

Glutathione Deficiency Contributes To Oxidative Stress Which Plays A Key Role In Aging And The Worsening Of Many Diseases Including Alzheimer's / Parkinson's / Liver Disease / Cystic Fibrosis / Sickle Cell Anemia / Hiv / Aids / Cancer / Heart Attack / And Diabetes To Name Only A Few.

Glutathione Is So Important To Health That Its Depletion Leads To Cell Death.

Environmental Toxins Are Known To Cause Depletion Of Glutathione

Efficient Liver Function Is Vital To The Overall Health Of The Body.

  • Optimum Liver Function Depends On Constant Supplies Of Antioxidant Nutrients. If The Liver Is Not Working Efficiently And Antioxidant Defenses Are Low The Effects Can Be Seen In Any Cell, Tissue Or Organ In the Body.
  • A vast constellation of symptoms can result from impaired liver function that at first glance may seem to have nothing at all to do with the liver. Over the last century the workload of our livers has increased significantly. A vast amount of chemicals are now in everyday use and all of these must be processed and neutralized by the liver. These chemicals come in the form of pharmaceutical drugs, household cleaning products, cosmetic and personal care products as well as household furnishings and building materials, to name but a few.

How Glutathione Aids in the Detoxification Process

  • During detoxification, the liver filters the blood, removing large toxins and unwanted chemicals / virus / bacteria. The liver filters everything ingested by the body and converts any toxins into water soluble chemicals that are expelled through either the Kidneys in urine or through the Colon in stool.
  • This generally occurs in a two-phase process. During phase I the liver either completely neutralizes toxins or modifies them into weaker, less harmful toxins. Toxins are reduced to smaller fragments, which can then be more easily neutralized in the next phase.
  • During phase II more powerful enzymes are produced which continue the detoxification process. GSH is produced during phase I, but released into the body, along with other antioxidants, during phase II. Antioxidants protect cells from oxidative damage caused by free radicals.
  • GSH is by far the most important antioxidant and is the only antixoidant produced by our cells in a natural process, GSH is utilized by our cells for neutralizing free radicals and is a principle component of phase 11 detoxification.
  • When a person is exposed to large amounts of toxins for long periods there is an imbalance between the two phases. When this occurs, key nutrients such as GSH levels are depleted. Liver damage and oxidative stress results in the phase 11 processes dependant on GSH failing to occur.

It is vital to supply the liver with the ability to replenish its own GSH in order to prevent oxidative stress from forming and damage occuring.

FUNCTIONS OF GSH IN LIVER:

  • GSH is carried in the bile to the intestinal luminal compartment, here GSH PROTECTS CELLS FROM TOXINS that enter the Intestine; enabling Intestinal integrity.
  • Metabolism of carbohydrates / lipids and proteins create oxidative stress -- GSH CONTROLS OXIDATIVE STRESS = better metabolism and less inflammation.
  • GSH MAINTAINS THE HEALTH OF THE LIVER CELLS so the liver can store vits and minerals.
  • Cellular GSH also AFFECTS THE GROWTH AND REPLICATION OF T-CELLS affects through growth stimulating cytokines.
  • RECYCLYING OF OTHER ANTIOXIDANTS (master antioxidant role) - Glutathione recycles oxidized lipoic acid, vitamin C and E by restoring them to an active state, mostly by donating the electrons that they used in metabolizing (neutralizing) free radicals. So, instead of having this army of antioxidants flushed out, they are recycled by Glutathione and sent back out to work.

NATURAL DETOXIFICATION (AID)

Whether we know it or not, we are continually inhaling and ingesting natural and synthetic toxins. They are unavoidable in these modern times, both in our polluted cities and our engineered food supplies. When the body has its health and is supplied the nourishment it needs; it works tirelessly to eliminate toxins and protect itself, however increasing levels of environmental pollution are depleting our concentrations of Glutathione more and more rapidly. This depletion comes from the utilization of GSH in removing more and more toxins from our bodies.

IT IS SAID THAT THE HEALTH OF THE LIVER IS THE DIRECT RESULT OF THE CONCENTRATION OF GSH IN THE LIVER.

Typically, when we are exposed to chemicals like alcohol and pollution which can damage the liver, the concentration of Glutathione in the liver is substantially reduced. This reduction makes the liver susceptible to damage by Ray Sahelian, M.D.

The Liver Involvement in Enviornmental Diseases

The importance of the gut flora in ill health is becoming increasingly obvious as it is implicated as a cause of an increasing number of illnesses.

The health of the gut has a substantial impact on the health of the liver as everything absorbed from the intestines passes through the liver so that harmful substances can be detoxified before the rest of the body is exposed to them. In one study by doctors at Biolab UK 61% of sufferers of undiagnosed chronic illnesses with predominant fatigue were found to have overgrowth of both bacteria and yeast in the gut. As a result of their normal metabolism these micro-organisms produce waste products that in increased amounts can be harmful to the LIVER and the persons health as a whole.

Yeast (CANDIDA) in particular produce a large amount of ethanol (drinking alcohol) which is highly toxic to the liver, in fact alcohol is the single most toxic substance to liver cells. As well as producing increased amounts of toxic substances for the liver to deal with, yeast or bacterial overgrowth also causes damage to the intestinal lining causing 'leaky gut'. Increased gut permeability results in even more potentially toxic substances from the gut being absorbed to put further stress on the livers detoxification pathways. As mentioned earlier, the liver requires large amounts of energy and nutrients to function efficiently. If the liver is overwhelmed by toxins, these nutrients can become depleted and the liver will function inefficiently resulting in numerous symptoms and problems throughout the body.

The above is the effect Glutathione has on our liver and its ability to act as a detoxifier. With Glutathione taking a central role in our daily detoxification program our liver has the means to extract the toxins from our cells. They are then more readily available to absorb nutrients and perform necessary functions that promote better health.

GSH is crucial for optimum liver function.

SOME DISEASES OF THE LIVER AND THE ROLE THAT GSH PLAYS
Alcohol And The Liver:

Alcohol is the most heavily consumed toxin in the world. Glutathione (GSH) is vital to your health, wellness, and longevity.

When the liver has too much alcohol to handle, normal liver function may be interrupted leading to a chemical imbalance. If the liver is required to detoxify alcohol continuously, liver cells may be destroyed or altered resulting in fat deposits (fatty liver), and more seriously, either inflammation (alcoholic hepatitis), and/or permanent scarring (cirrhosis). Liver cancer can also result from alcohol induced liver disease.
Alcohol Is A Major Glutathione Depleting Agent / Gsh Protects The Liver Cells.

AlcoholGSH represents the inseparable relationship between the detrimental effects of alcohol and the beneficial effects of Glutathione to health.
Study

In patients with hepatitis B virus infections, GSH and GSH/GSSG levels were significantly low compared with those in controls
AIM

To study reduced Glutathione (GSH) as a marker of oxidative stress in hepatitis E virus (HEV) infection its association during pregnancy, and to clarify with pregnancy outcome.
CONCLUSION

Oxidative stress is present in HEV infection during pregnancy, AS SHOWN BY LOW GSH, and is associated with adverse pregnancy outcomes.
Autoimmune Hepatitis:

Autoimmune hepatitis is a disease characterized by chronic inflammation of the liver. The best way to describe this disease is to break the term down into its composite words. Autoimmune refers to the body’s own immune system attacking another part of the body. Hepatitis refers to inflammation of the liver, which can range from mild to severe.
Conclusion:

Our results show that patients with chronic HCV infection are under the influence of oxidative stress associated with lower levels of antioxidant enzymes

HIGH OXIDANT MARKERS = LOW GSH AND A STRESSED STRUGGLING LIVER

  • Biliary Atresia (BA) - An important clinical problem involving impairments in bile flow that manifest as neonatal jaundice and can lead to progressive fibrosis and end-stage liver cirrhosis.
  • Oxidative stress and mitochondrial dysfunction are involved in the pathogenesis of chronic liver cholestasis.
  • Oxidative Stress In Cells Or Tissues Is An Abnormal Phenomenon that occurs when the production of oxygen radicals exceeds that of the antioxidant capacity. These excess free radicals damage essential cellular macromolecules, leading to abnormal gene expression and cell death.

Antioxidant enzymes catalyze the decomposition of these free radicals. The major antioxidant enzymes include Glutathione.

Disturbances In The Antioxidant System Could Play A Role In The Pathogenesis Of Chronic Liver Disease And Could Result In Different Types Of Liver Diseases In Infancy Cirrhosis And Complications / Liver Cancer

  • An Antioxidant System Of Cirrhosis And Hepatocellular Carcinoma is severely impaired.This is associated with changes of Glutathione level and activities of GSH-dependent enzymes in liver tissue.
  • GSH and enzymes cooperating with it are important factors in the process of liver diseases development.
  • Fatty Liver Disease - Abstract In chronic steatosic liver disease, alcohol or non-alcohol related or HBV, HCV, HDV associated, a reduction in hepatic Glutathione and, consequently, in the detoxifying effects of hepatocytes is observed.
  • GSH replenishing aids fatty liver disease Galactosemia
  • Membrane permeability is increased Gallstones, data show that gall stone patients have a high level of oxidative stress in the gall bladder mucosa, a finding that may be related to a decreased activity of functional enzymes in mucosal cells. Such a condition might result in an altered gall bladder absorption and secretion of bile components such as mucins and glycoproteins. The resultant increased risk of bile saturation would further contribute to the progress of gall stone formation. GSH REMOVES oxidative stress thererfore aiding gall bladder.
  • Hemochromatosis - whey protein ameliorates the oxidative changes induced by iron overload. In addition, whey protein supplementation fully inhibited iron overload-induced DNA damage in leukocytes and colonocytes.
  • A highly significant positive correlation was observed between plasma iron levels and DNA damage in leukocytes and colonocytes. These results show the antioxidative and antigenotoxic effects of whey protein in an in vivo model of iron overload-induced oxidative stress.
  • Porphyria - presence of metals in liver - GSH plays a key role in detoxification, having the ability to bind to heavy metals and other toxins through its sulfur molecules, thereby providing the means for the body to eliminate these toxins.
  • Sarcoidosis - DISCUSSION: The endogenous antioxidant defense was significantly reduced in sarcoidosis, indicating that oxidative stress underlies the pathology of this disease. Furthermore, the inflammatory status was significantly enhanced in sarcoidosis. GSH is the most effective method of removing inflammation in our body.
  • Viral Hepatitis A, B, C

2014 study - We concluded that the determination of antioxidant system, oxidative stress and liver function tests may be considered as accurate biomarkers for determining the progression of HBV infection. Also treatment with antioxidant supplementation is very important in case of HBV infection.

Adequate Glutathione is crucial for cell function in the Liver cells. Attaining adequate Glutathione is easy and effective if done correctly. Please contact me for more information.