- Efficient liver function is extremely important to the overall health of a person and this depends on constant supplies of
antioxidant nutrients. If the liver isn't working efficiently and antioxidant defenses are low, the effects can be seen in any cell,
tissue or organ in the body. A vast constellation of symptoms can result from impaired liver function that at first glance may seem
to have nothing at all to do with the liver.         

The liver has a number of important functions, some of the main ones being:

- Detoxification of potentially toxic chemicals from both inside and outside of the body including drugs, alcohol and   toxins from
intestinal microbes.
Accomplished with antioxidant nutrients and enzymes such as glutathione.
- Storage of sugar as 'glycogen' and regulation of blood sugar levels.
- Production and storage of proteins as well as the regulation of many substances involved in protein metabolism.
- Production of bile which aids in the digestion of fats.
- Production of blood proteins, clotting factors and substances important to the production of red blood cells (erythrocytes)
- Regulation of a number of hormones.
- Neutralization of 'free-radicals' by antioxidants. Free radicals are highly reactive oxygen molecules that can damage tissues.
- Storage of vitamins, mainly A, D and B12

As you can see the liver is involved in a wide array of metabolic activities and it requires a large amount of energy and nutrients to
accomplish these effectively.

Over the last century the workload of our livers has increased significantly. A vast amount of chemicals are now in everyday use
and all of these must be processed and neutralized by the liver. These chemicals come in the form of pharmaceutical drugs,
household cleaning products, cosmetic and personal care products and household furnishings and building materials, to name
but a few.


- Whether we know it or not, we are continually inhaling and ingesting natural and synthetic toxins. They are unavoidable in
these modern times, both in our polluted cities and our engineered food supplies. When the body has its health and the
nourishment it needs it works tirelessly to eliminate toxins and protect itself, but
increasing levels of environmental
pollution are depleting its stores of glutathione more and more rapidly.

Glutathione and the Liver

- Regarding the safety of glutathione in the liver, it is said that the levels of glutathione in the liver is critically linked to the  livers
capacity to detoxify.
This means that the higher the glutathione content, the greater the livers capacity to detoxify harmful chemicals and TOXINS.
Typically, when we are exposed to chemicals like alcohol and pollution which can damage the liver, the concentration of
glutathione in the liver is substantially reduced. This reduction makes the liver susceptible to damage.

What happens if Glutathione levels are low?  information by Ray Sahelian, M.D.

- Glutathione deficiency contributes to oxidative stress, which plays a key role in aging and the worsening of many diseases
including Alzheimer's disease, Parkinson's disease,
liver disease, cystic fibrosis, sickle cell anemia, HIV, AIDS, cancer, heart
attack, and diabetes.

Glutathione - The Master Antioxidant

Glutathione is an antioxidant enzyme often referred to as the body's "master antioxidant" due to its central role in protecting the
body's cells from free radical damage. Glutathione is composed of the amino acids cysteine, glutamine and glycine and
concentrated in the liver
, although it carries out its work throughout the body. This important enzyme is involved in protecting
cells from environmental toxins, drugs and alcohol as well as toxins produced by the body itself as a result of normal metabolism.


The Liver Involvment in  Enviornmental Diseases

- The importance of the gut flora in ill health is becoming increasingly obvious as it is implicated as a cause of an increasing
number of illnesses.
The health of the gut has a substantial impact on the health of the liver as everything absorbed from the intestines passes
through the liver so that harmful substances can be detoxified before the rest of the body is exposed to them.

In one study by doctors at Biolab UK 61% of sufferers of undiagnosed chronic illnesses with predominant fatigue were found to
have overgrowth of both bacteria and yeast in the gut. As a result of their normal metabolism these micro-organisms produce
waste products that in increased amounts can be harmful to the liver and the persons health as a whole. Yeast
(CANDIDA - any 9
strains of Candida )
in particular produce a large amount of ethanol (drinking alcohol) which is highly toxic to the liver, in fact
alcohol is the single most toxic substance to liver cells. As well as producing increased amounts of toxic substances for the liver
to deal with, yeast or bacterial overgrowth also causes damage to the intestinal lining causing 'leaky gut'. Increased gut
permeability results in even more potentially toxic substances from the gut being absorbed to put further stress on the livers
detoxification pathways.

A study of liver disease in alcoholics found that only the patients with a leaky gut developed cirrhosis of the liver. This points to
the possibility that in people with gut dysbiosis, not only is there chronic ingestion of alcohol but the leaky gut caused by bacterial
and/or yeast overgrowth leads to more severe effects on the liver from the alcohol produced. If the liver is overwhelmed by toxins
from the gut and from chemicals in everyday use it won't function correctly and may even become damaged and inflamed. As a
result, not all toxins entering the liver are detoxified and gain access to the bloodstream to travel anywhere in the body. These
toxins and the excess of free radicals (highly reactive forms of oxygen) caused by poor liver function can cause direct damage to
tissues and also initiate allergic or auto-immune reactions. Un-neutralized toxins are also expelled into the bile in this situation and
can further damage the intestinal lining, setting up a vicious cycle in which gut dysbiosis and leaky gut cause poor liver function
which in turn worsens the gut dysbiosis and leaky gut.  And the cycle continues and worsens unless help is given.

As mentioned earlier, the liver requires large amounts of energy and nutrients to function efficiently. If the liver is overwhelmed by
toxins, these nutrients can become depleted and the liver will function inefficiently resulting in numerous symptoms and problems
throughout the body. Many of these nutrients can be replaced by supplementation, improving the functioning of the liver.

Research shows that when Glutathione is adequate in the body it is in every cell and is in high concentrations
esp in LUNGS / LIVER AND BRAIN.   You can see why when one important job Glutathione accomplishes in the
body is detox,   liver and lungs are the detox organs of the body.

Glutathione helps liver research:

J Med. 2000;31(5-6):283-302.
Nutritional therapy of chronic hepatitis by
whey protein (non-heated).
Watanabe A, Okada K, Shimizu Y, Wakabayashi H, Higuchi K, Niiya
K, Kuwabara Y, Yasuyama T, Ito H, Tsukishiro T, Kondoh Y, Emi N,
Kohri H.
Third Department of Internal Medicine, Toyama Medical and
Pharmaceutical University, Toyama, Japan.
In an open study the clinical efficacy of milk serum (whey) protein (Immunocal; cysteine
content: 7.6-fold higher than that of casein) isolated from fresh milk and purified without
heating was evaluated in 25 patients with
chronic hepatitis B or C. Immunocal (12 g as
protein) food (mousse) was given twice a day, in the morning and evening, for 12 weeks
(test period). Casein (12 g as protein) food (mousse) was similarly given for two weeks
prior to the start of the supplement with Immunocal food (induction period) and for four
weeks after the end of the supplement with Immunocal food (follow-up period). Serum
alanine aminotransferase (ALT) activity was reduced, and plasma glutathione (GSH)
levels increased in six and five of eight patients with chronic hepatitis B, respectively, 12
weeks after the start of the supplement with Immunocal food. Serum lipid peroxide levels
significantly decreased, and interleukin (IL)-2 levels and natural killer (NK) activity
significantly increased. However, there were no significant Immunocal-related changes in
17 patients with chronic hepatitis C.
These findings suggest that the long-term
supplement with Immunocal alone may be effective for improving liver dysfunctions in
patients with chronic hepatitis B.
PMID: 11508322 [PubMed - indexed for MEDLINE]


- GSH-Immunity® contains Lactoferrin which helps scavenge free iron with remarkable efficiency

Can J Cardiol. 2003 Sep;19(10):1163-8.
Related Articles, Links

Milk whey protein decreases oxygen free radical production in a murine model of chronic iron-overload cardiomyopathy.

Bartfay WJ, Davis MT, Medves JM, Lugowski S.

Faculty of Nursing, University of Windsor, Windsor, Ontario, Canada.

Chronic iron overload is a major cause of organ failure worldwide, but its pathogenesis remains to be elucidated.
OBJECTIVES: To examine in an experimental murine model of iron-overload cardiomyopathy the relation between milk whey
protein and, first, the production of reactive oxygen free radical species and, second, antioxidant reserve status. METHODS:
B6D2F1 mice were randomly assigned to four treatment groups (n=8 per treatment group): placebo control; iron only; whey only;
and iron with whey. Reactive oxygen free radical species in the heart were quantified by the cytotoxic aldehydes malondialdehyde
(MDA), 4-hydroxy-nonenal (HNE) and hexanal, while antioxidant reserve status was quantified by glutathione (GSH) and
glutathione peroxidase (GPx) activity in the heart tissue. RESULTS: Significantly decreased concentrations (pmol/100 mg wet
weight tissue) of MDA (2468+/-261), HNE (912+/-38) and hexanal (5385+/-927) were observed in the heart tissue of the group
receiving iron with whey, in comparison with the iron-only treatment group (MDA 9307+/-387, HNE 1416+/-157, hexanal
14,874+/-2955; P<0.001). Significantly increased GPx (141+/-38 IU/L) and GSH (521+/-136 IU/L) activity were observed in mice
receiving iron with whey, in comparison with mice receiving iron only (GPx 100+/-10 IU/L, GSH 446+/-33 IU/L; P<0.001).
CONCLUSION: Mice receiving iron treatments with whey supplementation had significantly lower concentrations of cytotoxic
aldehydes and significantly higher cardiac levels of GPx and GSH activity than did iron-only treated mice.
Additional basic
research is warranted to examine the exact mechanisms by which milk whey protein protects the heart.
Recenti Prog Med. 1995 Jul-Aug;86(7-8):290-3.

"Glutathione in the treatment of chronic fatty liver diseases"

Dentico P, Volpe A, Buongiorno R, Grattagliano I, Altomare E, Tantimonaco G, Scotto G, Sacco R, Schiraldi O.
Istituto Policattedra, Università, Bari.

In chronic steatosic liver disease, alcohol or non-alcohol related or HBV, HCV, HDV associated, a reduction in hepatic glutathione
and, consequently, in the detoxifying effects of hepatocytes is observed. Intravenous
administration of high dose glutathione in
patients with chronic steatosic liver disease has shown that glutathione significantly improves the rate of some hepatic tests
(bilirubin, GOT, GPT, GT) even several months after treatment interruption.
Further confirmation of the efficacy of GSH treatment is
provided by the reduction of malondialdehyde, a marker of hepatic cell damage. The optimal results obtained in patients receiving
1800 mg/die/i.v. advocate the use of this high dosage.

PMID: 7569285 [PubMed - indexed for MEDLINE]

"Glutathione in liver diseases and hepatotoxicity."
Friday, February 6th, 2009
Mol Aspects Med. 2008 Aug 26. [Epub ahead of print]

Yuan L, Kaplowitz N.
Internal Medicine, University of Southern California, USA; Los Angeles County (LAC) Medical Center Los Angeles, CA 90033, USA.

Glutathione (GSH) is a major antioxidant as well as redox and cell signaling regulator. GSH guards cells against oxidative injury by
reducing H(2)O(2) and scavenging reactive oxygen and nitrogen radicals. In addition, GSH-induced redox shift with or without
ROS subjects some cellular proteins to varied forms of oxidation, altering the function of signal transduction and transcription
factor molecules.
Increasing evidence supports the important role of ROS and GSH in modulating multiple signaling pathways.
TNF-alpha and Fas signaling, NF-kappaB, JNK and mitochondrial apoptotic pathways are the focus of this review. The redox
regulation either can switch on/off or regulate the threshold for some crucial events in these pathways. Notably, mitochondrial
GSH depletion induces increased mitochondrial ROS exposure which impairs bioenergetics and promotes mitochondrial
permeability transition pore opening which is critical for cell death. Depending on the extent of mitochondrial damage, NF-kappaB
inhibition and JNK activation, hepatocytes may either undergo different modes of cell death (apoptosis or necrosis) or be
sensitized to cell-death stimuli (i.e. TNF-alpha). These processes have been implicated in the pathogenesis of many liver diseases.

PMID: 18786561 [PubMed - as supplied by publisher]

       As you can see Glutathione plays an extremely important role in Liver function.  

This chart shows the normal rate of depletion of Glutathione in a body with age.   This does not include  the "extra" depletion in
the body caused from pollution toxins,  disease, injuries ( life!) .  Reading
this information you can see that REPLENISHING GLUTATHIONE in the
body to MAINTAIN an adaquate level can certainly help the body to maintain
health and a most easier life being  healthy and helping to PREVENT such
diseases of old age. Keeping the organs such as the Liver healthy goes
along way to enhancing the longevity of the body.  You stand a good chance
of aging gracefully to a time that can be enjoyed




                                    Please contact me via phone (250 - 422 - 3163 ) or email  for information on how to purchase
   GSH-Immunity®       The Choice of Professionals!

Peggy Maki:
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