Lyme and Co Infections

NATURAL GUIDE TO HEALTH LYME DISEASE
SUPPORT FOR FIGHTING LYME DISEASE AND CO INFECTIONS

About Lyme Disease:

Since the discovery over thirty years ago of the spirochete bacteria, Borrelia burgdorferi (Bb), responsible for causing Lyme disease, much research and information has come to light around this serious health issue. Lyme is probably the most political and controversial disease of these times. The bacteria are transmitted from the bite of a tick to its host, which can include animals such as deer, squirrels, raccoons, skunks, small rodents, birds, pets and people. In the United States and Europe, where much of the research is being conducted, researchers consider Lyme a larger pandemic than Cancer and AIDS with estimates of up to 200,000 new cases a year in the United States alone.

The Politics of Lyme Disease:

Lyme is often under-diagnosed or misdiagnosed. Those with Lyme disease often have other bacterial co-infections such as Bartonella, Babesia and Ehrlichia and they are often lumped together with Lyme disease. The standard medical therapy for Lyme and its co-infections is the use of antibiotics. The current regulations of a maximum of six weeks of antibiotic use can be effective for treating an initial infection; it is, however, not long enough, for treating chronic Lyme.  In both the U.S. and Canada, there seems to be a schism in the medical community. On the one side, the regulatory bodies of allopathic or mainstream medicine insist that chronic Lyme disease does not exist and medical doctors are only allowed to treat recognized diseases. On the other side are Lyme Literate Medical Doctors (LLMD) and complementary practitioners who recognize chronic Lyme exists and that it is both under-diagnosed and misdiagnosed.

Chronic Lyme Testing:

To date, there is no test that is 100% accurate for detecting BB, which makes it difficult to diagnose. The two approved tests in Canada and the U.S. are the ELISA and the Western Blot. These tests measure the body’s immune response to the bacteria or antibody levels in the blood and not the presence of the bacteria. Both of these tests have recognized limitations, including up to fifty percent false negative results. Another test, the Lyme Dot Blot Assay or LDA, measures the Lyme antigen or bacteria levels in the urine and not the body’s immune response. In chronic Lyme, BB is not necessarily circulating in the blood and does therefore not always show positive on the above tests. THE BACTERIA INHABITS INTERCELLULAR TISSUE, including immune cells and may only be detectable through biopsy and autopsy. The bacteria have also shown the capability to form cysts. The cyst form of BB allows the bacteria to evade the body’s immune system and even antibiotics. These cysts are considered the major reason for relapses.

Lyme the Great Imitator

The reason Lyme disease is known as the Great Imitator is because it can manifest in any part of the body with many different symptoms. There is no single unique expression for Lyme and it can infect every system and organ in the body.

 Neurological Lyme:

Neurological Lyme or neuorborreliosis can manifest as Alzheimers, ALS, Autism, Parkinsons, Bell's Palsy or MS.

Multiple Sclerosis (MS):

Multiple Sclerosis is a chronic central nervous system infection similar to Lyme disease or Neurosyphilis in its latency period / pathogenesis / symptoms / histopathology and  / chronic CNS involvement

Research:

In the late period of Lyme disease demyelinating involvement of the central nervous system can develop and MS can be erroneously diagnosed; 2007;69 (1):117-9. Epub 2007 Jan 2

Other recognized forms of Lyme include Arthritic Lyme, Cardiac Lyme, Ocular Lyme and Auditory Lyme. Chronic fatigue, chronic pain or fibromyalgia symptoms are common. Coincidentally or not, the term fibromyalgia and chronic fatigue syndrome were coined during the same time period as a resistance to recognizing chronic Lyme disease became the norm.

Some of the other symptoms and conditions that can indicate Lyme disease include constant headaches or migraines, night sweats, heart palpitations, neck pain, jaw and teeth pain, anxiety, sleep disorders, fatigue, memory issues (Lyme fog) and autoimmune disorders.

Less than half of Lyme infected individuals bitten by a tick, develop the classical bulls eye rash or erythema migrans (EM). As a result, many individuals may not realize they are infected. Within weeks of infection, individuals often develop flu-like symptoms and can experience a significant deterioration in their health, either gradually or rapidly. Many do not develop symptoms for years.

When using antibiotics or natural antibacterial remedies, the body can experience a die off of the bacteria. This causes what is known as a Herxheimer reaction or a flare up of the symptoms. The patient can initially feel worse, which may lead them to believe, incorrectly, that they are having an adverse reaction to the remedy. These reactions can actually indicate that the remedy is working. Lyme sufferers may experience many Herxheimer reactions throughout the curative process.

FACTS ABOUT LYME: Only 1 In 2 People Develop The Classical Bull's Eye Rash.

  • As many as 64% of people do not remember being bitten by a tick.
  • Standard blood testing for Lyme has an estimated sensitivity of less than 50% blood tests might not show correct results.
  • Most ticks carry multiple disease causing pathogens called CO Infections.
  • A tick can host up to 30 different pathogens. Species that are not tested by current CDC guidelines are: Babesia, Bartonella, Mycoplasma Ehrlichia / Anaplasma and more.
  • Many of these Co infections do not respond to standard Lyme treatment.
  • An average person suffering from Lyme takes 2 - 3 years to be diagnosed correctly. This allows Lyme plus the Co infections to become very well established in the body many at this time are in a chronic infected state.
  • Lyme can cause over 300 symptoms
  • Lyme disease pathogens can affect multiple body systems, thus producing a large range of symptoms. These diverse symptoms often can cause a lacking in correct diagnosis.
  • Tick nymph can be smaller than the period at the end of a sentence; it is very easy to miss the tick.
  • Lyme disease is more epidemic than aids, west nile and avian flu combined.
  • The CDC estimates that there are over 325,000 new cases of ld diagnosed in the US each year, this does not include the numbers of people misdiagnosed.
  • The Lyme disease bacterium can survive the antibiotics in the initial treatment of Lyme.
  • The 2 - 4 week course of antibiotic does not necessarily guarantee the complete eradication of Lyme disease pathogens plus Co infections.
  • New research shows that Lyme disease pathogens plus Co infections are highly adapted or mutate very easily thus evading the antibiotic treatment.
  • Research shows that short term treatment for Lyme, is not effective in over 90% of persons with Lyme.
  • There are 12 strains of Borrelia that are known to cause Lyme disease; however testing is only effective on ONE strain.
  • A Lyme disease transmission might not be limited to tick bites, in addition to ticks Lyme disease might be transmitted via mites, fleas and mosquitoes.

LYME DISEASE /// CO INFECTIONS /// GSH FIGHTS THIS FIGHT EFFECTIVELY

How can replenishing GSH aid the fight against Lyme disease and Co Infections?

  • Glutathione is found in EVERY cell in your body. We are so bombarded with free radicals in the form of radiation, electromagnetic radiation, air pollution, toxic metals, VIRUS / BACTERIA, fungi, molds, chemicals, pesticides, stress, etc.
  • Glutathione scavenges these free radicals, detoxifies heavy metals, RECOGNIZES ALL BACTERIA AND VIRUS THEN REMOVES THEM FROM THE BODY.
  • With all of its capacities, Glutathione is CRUCIAL FOR MAINTAINING IMMUNITY. Lyme Disease is a disease with critically stressed Immune functions.
  • Lyme disease and the ensuing physical difficulties it brings from the BB infection makes Glutathione the most important therapeutic substance. Why, because GLUTATHIONE IS A MAJOR FACTOR IN LIMITING THE DAMAGE TO THE CELLS THAT OCCURS WITH LYME DISEASE.

Can Glutathione Help those that have Lyme Disease?

(Excerpt from: The Glutathione Report: Optimal Health with the Master Antioxidant, Issue 4, Volume 1, May 2004).

  • Glutathione, is a potent free radical scavenger which neutralizes toxins (especially those in the liver, where Glutathione is found in high concentrations).
  • Glutathione aids in repair and synthesis of DNA and help maintain red blood cell membrane integrity.
  • Glutathione is especially powerful in neutralizing toxins in Lyme disease because IT CAN RENDER INACTIVE THE NEUROTOXINS PRODUCED BY BB.
  • This is so important because it can DECREASE NEUROLOGICAL SYMPTOMS AND PROTECTS THE NERVOUS SYSTEM FROM DAMAGE.
  • Low Glutathione means: less ability to detoxify free radicals, less ability to clear heavy metals, lower Immune function, increased inflammation, and lower levels of Vitamin C and Vitamin E, antioxidants that depend on Glutathione.
  • Lyme diseases is a complex problem on immunological dysfunction, which is triggered by bacterial exotoxins. Glutathione forms soluble compounds with the exotoxic and mycotoxic acids that it is removing. Then it secretes these toxins through the gut, REMOVING THE TOXINS / VIRUS / BACTERIA.
  • Lyme disease has as one of its main bacteria, Borrelia, producing a lot of toxins which trigger many harmful bodily responses, including producing inflammation, damaging healthy tissues, and cause the Immune system to become Unbalanced and Weakened. The toxins that are created by the Borrelia are fat-soluble lipoproteins; the body has a very difficult time ridding the body of these. In the normal bodily process of detoxifying fat-soluble substances through the liver they are excreted from the bile. But the problem occurs when these toxins can then be reabsorbed from the gut and recirculate back into the body. Therefore, IT IS CRITICAL IN LYME DISEASE THAT THERE IS A WAY TO AID THE BODY IN ELIMINATING THESE TOXINS FROM THE BODY COMPLETELY AND EFFECTIVELY. ALLOWING OUR CELLS TO REPLENISH THEIR OWN GSH IS THAT CRITICAL FACTOR OFTEN MISSING IN LYME PROTOCOLS.

THE MOST IMPORTANT DETOXIFYING AGENT IN THE BODY IS GLUTATHIONE. IT AIDS THE BODY IN RIDDING HARMFUL TOXINS SUCH AS THOSE BLP'S (bacterial lipoproteins) PRODUCED BY BORRELIA BURGDOFERI (BB).

The importance of Glutathione

  • When GSH attaches to the toxins they DO NOT REABSORB IN THE GUT AND GO BACK INTO THE BLOOD.
  • Glutathione forms a soluble compound with the toxin that is excreted through the urine or the gut.
  • The kidney and liver get the greatest exposure to toxins they require high concentrations of Glutathione, because of their front line protection to the body from toxins.
  • We need protection in the cells from oxygen radicals, or free radicals. Glutathione IS MADE BY THE CELLS TO PROTECT THE CELLS!!! When the highly reactive oxygen radicals and free radicals are not taken care of, they will damage or destroy the most key and important facets of a cells components: cell membranes / DNA in microseconds.
  • When the cell burns oxygen to make energy in the thousands of mitochondria inside each cell, high amounts of oxygen radicals are generated. Something has to put out this fire; that was the after burn of the mitochondria (the batteries that provide the power for our cells to function). GLUATHIONE IS THAT MUCH NEEDED SUBSTANCE THAT PUTS OUT THE FIRES!!!
  • When there is some kind of inflammation created by fungi, molds, virus, bacteria, toxins, pollutants, etc., the cell produces more free radicals from the hyper immune response. This product of free radicals must also be dealt with; THE MOST EFFICIENT METHOD OF ACCOMPLISHING REMOVING THE FREEE RADICALS IN THIS SITUATION IS WITH GLUTATHIONE.
  • WE NEED ADEQUATE CONCENTRATIONS OF GLUTATHIONE IN THE MOST INTRICATE OF STEPS
  • NEEDED TO CARRY OUT AN IMMUNE SYSTEM RESPONSE. One such response requiring adequate concentrations of Glutathione are the lymphocytes that must multiply in order to support the development of a strong immune response.
  • Yet another example of the need for Glutathione is to AID THE KILLER LYMPHOCYTES TO BE ABLE TO KILL UNDESIRABLE CELLS AS IN CANCER CELLS OR CELLS INFECTED WITH VIRUS OR BACTERIA.


One of the most trusted names in Lyme medicine is that of Robert Bransfield, MD. For those who don't know who he is, Dr. Bransfield is a practicing psychiatrist from New Jersey who is also a long-time member of the International Lyme and Associated Diseases Society (ILADS). He is a recognized expert in the psychiatric and neurological manifestations of Lyme disease.

Dr. Bransfield published a very important article in December, 2007, in Psychiatric Times (www.psychiatrictimes.com) entitled "Lyme Disease, Comorbid Tick-Borne Diseases, and Neuropsychiatric Disorders". In this article, written primarily for practicing psychiatrists, he effectively presents the medical aspects of Lyme as it affects the brain with resulting neurological and psychiatric manifestations.

He begins by discussing the fact that Lyme has taken the place of its cousin, syphilis, as the "new great imitator". But Lyme represents much more a challenge because it is more difficult to diagnose properly and more difficult to eliminate. Combining these two factors with the confusion that is often generated by the presence of co-infections, it makes Lyme medicine the "ultimate" challenge for the average medical practitioner. Frequent symptoms listed by Dr. Bransfield include: fatigue, cognitive impairments, depression, anxiety, irritability, headache, and a multitude of other symptoms. Often fibromyalgia, chronic fatigue syndrome, or multiple sclerosis (MS) has been diagnosed.

Dr. Bransfield suggests that Lyme disease be considered in patients who have no history of previous psychiatric, psychosomatic, or hypochondriacal problems who develop an increasing number of somatic (bodily symptoms), cognitive (mental functioning), neurological, and psychiatric symptoms. Most of the time, he states, a patient will have seen multiple specialists by the time he or she gets to the psychiatrist. Very often he or she will be on tranquilizers and antidepressant medications. Generally, a patient is sent to the psychiatrist for one of three reasons: (1) the symptoms of a patient are unexplainable medically and therefore the referring doctor suspects a psychosomatic or "somatoform" disorder, (2) the mental symptoms are too complex and require psychiatric assessment, or (3) a psychiatrist is needed in order to help manage psychiatric treatments or medications.

Psychiatric manifestations of the tick-borne illnesses are extremely common, and all of the chronic tick-borne infections can cause these manifestations. Anxiety and depression seem to be the main issues that Lyme practitioners most frequently face. Because of the frequency of these problems, the rate of severe psychiatric complications, such as suicide, is very high among tick-borne infection sufferers. Lyme patients (and their families) often describe unusual amounts of "irritability", often described as having a "short fuse". Lyme rage, commonly caused by Bartonella or Lyme, can be a significant cause of violence. Severe anxiety in a person with no history of psychiatric problems or in a person where the anxiety is far out of proportion to the life circumstances should be a major clue to the presence of a tick-borne illness. As Dr. Bransfield says, any psychiatric symptom with associated constitutional symptoms (such as arthritis, muscle pain, fatigue, brain fog, etc.) should be thoroughly investigated for Lyme or other tick-borne illness, or be referred to a qualified Lyme practitioner (preferably an ILADS member) for proper evaluation.

THIS DOCTOR CONSIDERS GLUTATHIONE (GSH) TO BE ONE OF THE MOST IMPORTANT HEALING MODALITIES OF LYME AND OTHER TICK-BORNE ILLNESSES. IT IS THE MOST IMPORTANT ANTIOXIDANT PRODUCED BY THE BODY. GSH IS CRITICAL FOR BRAIN HEALTH, LIVER HEALTH, AND THE HEALTH OF VIRTUALLY EVERY CELL OF THE BODY.

Research:

2001 : CONCLUSION:

In patients with Erythema migrans, the decreased capability to reduce lipid super oxidants leads to maintaining a high concentration of membrane lipid peroxidation products - Primary whey - GSH-Immunity supplies the Cysteine to the cells so they can replenish their own GSH, the lipid peroxidation product EXTREME EFFICIENCY.

2003 : CONCLUSION:

Cause and effect links between GSH metabolism and diseases such as cancer, neurodegenerative diseases, cystic fibrosis (CF), HIV, LYME and aging have been shown. Polymorphic expression of enzymes involved in GSH homeostasis influences susceptibility and progression of these conditions.

2015 : CONCLUSION:

Agents that affect cell membranes, energy production, and ROS production are generally more active against the B. Burgdorferi persistence than the commonly used antibiotics that inhibit macromolecule biosynthesis.

2008 :

Klonopin (clonazepam) "depletes the body of essential vitamins, minerals, Melatonin and Glutathione (the body’s master antioxidant)." THIS DRUG CAN BE USED FOR LYME DEPRESSION!

THIS IS EXTREMELY INTERESTING AND INFORMATIVE: ENJOY

LYME INFO NOTE: Dr. Van Konynenburg is a proponent of the Glutathione Depletion--Methylation Cycle Block hypothesis for the pathogenesis of CFS.

Review of the Glutathione Depletion-Methylation Cycle Block (GD-MCB) Hypothesis for CFS

  • 1.The person inherits a genetic predisposition (polymorphisms in several of certain genes toward developing CFS. (This genetic factor is more important for the sporadic cases than in the cluster cases of CFS.)
  • 2.The person then experiences some combination of a variety of possible stressors (physical, chemical, biological, psychological/emotional) that place demands on glutathione.
  • 3.Glutathione levels drop, producing oxidative stress, removing protection from B12, allowing toxins to accumulate, and shifting the immune response to Th2.
  • 4.Toxins react with B12, lowering the rate of formation of methylcobalamin. Lack of sufficient methylcobalamin inhibits methionine synthase, placing a partial block in the methylation cycle.
  • 5.Sulfur metabolites drain through the transsulfuration pathway excessively, pass through sulfoxidation, and are excreted.
  • 6.A vicious circle is established between the methylation cycle block and gluathione depletion, and the disorder becomes chronic.

Depletion of glutathione by Borrelia burgdorferi

  • 1.BB requires cysteine for its metabolism.
  • 2.Cysteine diffuses passively into BB from its host, i.e. there is no active transporter protein.
  • 3.BB uses cysteine in the synthesis of several of its essential enzymes: Osp A, Osp B, CoASH, a hemolysin, and others.
  • 4.BB does not use glutathione for its redox control. Instead, it uses reduced Coenzyme A (CoASH).
  • 5.Cysteine is the rate-limiting amino acid for the synthesis of glutathione in humans, so that the depletion of cysteine will produce depletion of glutathione.
  • 6.BB lowers the cysteine and gluathione levels in its human host, and inhibits the activity of glutathione peroxidase.
  • 7.Low glutathione and low activity of glutathione peroxidase allow a rise in hydrogen peroxidase concentration and oxidative stress.
  • 8.Elevation of hydrogen peroxide causes BB to assume its cyst form, in which it is less vulnerable to antibiotics.

New hypothesis for a link between Lyme disease and chronic fatigue syndrome

  • 1.Borrelia burgdorferi (BB) DEPLETE GLUTATHIONE IN THE HOST.
  • 2.For a person who is genetically susceptible to developing CFS, this provides a link to the GD-MCB hypothesis for CFS and is one of the possible routes into this disorder.
  • 3.If BB and its biotoxin were not eliminated, Lyme disease and CFS would coexist in the host, and THIS WOULD CONSTITUTE THE "CHRONIC LYME DISEASE".
  • 4.If BB and its biotoxin were eliminated, but the methylation cycle block continued, the person would continue to be ill with CFS. This would constitute "POST LYME DISEASE SYNDROME ", which would be analogous to the other post-infective fatigue syndromes.
  • 5.If BB and its biotoxin were eliminated and the methylation cycle block was lifted, i believe it is likely that the person would become well again.